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Graphical presentation of CX-5461-mediated activation on the cytosolic DNA sensing pathway. cGAS binding for the cytosolic DNA activates the secondary messenger 2,three-cGAMP employing cGAS being a catalyst. Activated STING buds off the ER shifting to the perinuclear Golgi, wherever it is palmitoylated.Perturbational screens in these cell lines hav

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